{"id":6475,"date":"2025-10-21T15:30:29","date_gmt":"2025-10-21T13:30:29","guid":{"rendered":"https:\/\/bacteria.de\/insight\/sucralose-sabotiert-immuntherapie\/"},"modified":"2025-11-04T11:24:18","modified_gmt":"2025-11-04T10:24:18","slug":"sucralose-sabotage-immunotherapy","status":"publish","type":"insight","link":"https:\/\/bacteria.de\/en\/insight\/sucralose-sabotage-immunotherapy\/","title":{"rendered":"Sucralose sabotages cancer treatment"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\">Sucralose sabotages cancer treatment<\/h1>\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><\/p>\n<\/blockquote>\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>What if a harmless sweetener prevents the success of cancer treatment? A new study shows that sucralose, the ubiquitous artificial sugar substitute, can affect the immune system to such an extent that modern immunotherapies lose their effectiveness. <\/p>\n<\/blockquote>\n\n<p>Researchers from the UPMC Hillman Cancer Center and the University of Pittsburgh report a previously unknown effect of <a href=\"https:\/\/bacteria.de\/en\/nutrition\/sucralose-poison-microbiome\/\" data-type=\"link\" data-id=\"https:\/\/bacteria.de\/ernaehrung\/sucralose-gift-mikrobiom\/\">sucralose<\/a> in Cancer Discovery: In mouse models and in patients with melanoma and non-small cell lung cancer, increased consumption of the sweetener led to significantly reduced efficacy of modern cancer immunotherapies.<\/p>\n\n<p><\/p>\n\n<h2 class=\"wp-block-heading\">How does immunotherapy work?<\/h2>\n\n<p>These therapies work by releasing certain &#8220;brakes&#8221; on the immune system, known as immune checkpoints. Normally, these checkpoints prevent immune cells from attacking the body&#8217;s own cells. Many tumors use this mechanism to camouflage themselves and evade the immune response. Checkpoint inhibitors remove this camouflage and activate T cells, which then destroy cancer cells in a targeted manner.   <\/p>\n\n<p><\/p>\n\n<h2 class=\"wp-block-heading\">How does sucralose interfere with immunotherapy?<\/h2>\n\n<p>But sucralose throws this finely tuned system out of balance. The sweetener alters the intestinal microbiome, reduces the diversity of beneficial bacteria and weakens T-cell activity. The result: a dampened immune response and less successful treatment. In the experiments, even the quantities achieved through the consumption of light drinks showed clear effects.   <\/p>\n\n<p>Although the authors emphasize that further studies are still needed, the data illustrate how strongly diet, microbiome and immune defense are linked.  <\/p>\n\n<p><strong>What tastes sweet can end bitterly in cancer treatment.<\/strong><\/p>\n\n<p><\/p>\n\n<h3 class=\"wp-block-heading\">What is important to you &#8211; in a nutshell!<\/h3>\n\n<ol class=\"wp-block-list\">\n<li>Sucralose alters the intestinal microbiome and dampens the immune system.<\/li>\n\n\n\n<li>Immunotherapies lose their effectiveness as a result<\/li>\n\n\n\n<li>Even realistic consumption levels show effects.<\/li>\n\n\n\n<li>Nutrition and the microbiome directly influence the success of therapy.<\/li>\n<\/ol>\n\n<p><\/p>\n\n<p>Read more on Bacteria.de: <a href=\"https:\/\/bacteria.de\/en\/nutrition\/sucralose-poison-microbiome\/\" data-type=\"link\" data-id=\"https:\/\/bacteria.de\/ernaehrung\/sucralose-gift-mikrobiom\/\">Sucralose &#8211; the sweet poison<\/a><\/p>\n\n<h5 class=\"wp-block-heading\">Source:<\/h5>\n\n<p>Cancer Discovery (2025) &#8211; Sucralose consumption ablates cancer immunotherapy efficacy, DOI: 10.1158\/2159-8290.CD-25-0247<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sucralose can sabotage cancer treatment and thus jeopardize its success.<\/p>\n","protected":false},"featured_media":6434,"template":"","meta":{"_et_pb_use_builder":"off","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"insight-topic":[259],"class_list":["post-6475","insight","type-insight","status-publish","has-post-thumbnail","hentry","insight-topic-nutrition"],"_links":{"self":[{"href":"https:\/\/bacteria.de\/en\/wp-json\/wp\/v2\/insight\/6475","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bacteria.de\/en\/wp-json\/wp\/v2\/insight"}],"about":[{"href":"https:\/\/bacteria.de\/en\/wp-json\/wp\/v2\/types\/insight"}],"version-history":[{"count":0,"href":"https:\/\/bacteria.de\/en\/wp-json\/wp\/v2\/insight\/6475\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bacteria.de\/en\/wp-json\/wp\/v2\/media\/6434"}],"wp:attachment":[{"href":"https:\/\/bacteria.de\/en\/wp-json\/wp\/v2\/media?parent=6475"}],"wp:term":[{"taxonomy":"insight-topic","embeddable":true,"href":"https:\/\/bacteria.de\/en\/wp-json\/wp\/v2\/insight-topic?post=6475"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}